Dr. SIVANANDAM M
Dr. SIVANANDAM M
Assistant Professor lll, Engineering Physics
Areas of Interests: Computational Biophysics, Bioinformatics, Computer Aided Drug Design, Quantum Chemical Calculations, Quantum Pharmacology, Crystallography.
Portfolios: Course Coordinator - Engineering Physics, HPC - Incharge, Physics Laboratory - Incharge, Chief Mentor - IT - C
ORCID: https://www.webofscience.com/wos/author/record/S-6266-2018
PhD Supervision ID: 4270010
Scholars Pursuing: 0
Scholars Completed: 0
About me
My research interests are in the areas of Computational Biology and Chemistry, Bioinformatics, Computer Aided Drug Design, Computational Biophysics, Quantum Chemical Calculations, Crystallography etc. I wish to collaborate with different research areas expert; such as, Chemistry, Biochemistry, Biotechnology, Microbiology and Botany. The research area includes HIV, Hepatitis, Parkinson, Alzheimer, Cancer, Epilepsy, Human Papilloma virus (HPV) and recent pandemic disease SARS Covid-19. I am interested in protein-ligand interactions, chemical reactions of enzyme (QM/MM), DNA-Ligand interactions, Protein conformational dynamics and Quantum Pharmacology.
Professional Information
- 1. 7th International Conference on Recent Innovations in Modern Science and Technology (ICRIMST-2024) - 2 Lakhs - Co-PI
- Indian Crystallographic Association (ICA)
- Centre for Development of Advanced Computing (C-DAC), Pune.
- Molecular Graphics and Modelling Society
- IAENG Society of Artificial Intelligence
- IAENG Society of Bioinformatics
- IAENG Society of Chemical Engineering
- IAENG Society of Scientific Computing
- Indian Association for Crystal Growth (IACG)
- World Academy of Sciences (WAS), Greece.
- International Association of Engineers – Hong Kong
- 1. Insights into Intermolecular interactions, electrostatic properties and the stability of C646 in the binding pocket o
- 2. Investigation of activation mechanism and conformational stability of N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxyb
- 3. Investigation of Intermolecular interactions and Stability of Verubecestat in the active site of BACE1: Development o
- 4. Probing the “fingers” domain inhibition–a new allosteric site of Hepatitis C virus NS5B RdRp via Docking and Molecula
- 5. Exploring the different environments effect of Piperine via combined Crystallographic, QM/MM and Molecular dynamics s
- 6. Binding mechanism of spinosine and venenatine molecules with p300 HAT enzyme – Molecular screening, molecular dynamic
- 7. Identification of a Novel flavonoid Inhibitor of Catechol-O Methyltransferase enzyme by Computational Screening - thr
- 8. Insights of inhibition mechanism of Sifuvirtide and MT-Sifuvirtide against wild and mutant 2 HIV-1 envelope glycoprot
- 9. Binding mechanism, conformation and stability of diflunisal and mycophenolic acid with p300 HAT enzyme using molecula
- 10. Design and Molecular dynamic Investigations of 7,8-Dihydroxyflavone Derivatives as Potential Neuroprotective Agents
- 11. Isolation of hesperetin - A flavonoid from Cordia sebestena flower extract through antioxidant assay guided method a
- 12. Experimental and Theoretical charge density, Intermolecular interactions and Electrostatic properties of Plumbagin
- 13. Possibility of HIV-1 protease inhibitors-clinical trial drugs as repurposed drugs for SARS- 2 CoV-2 main protease: A
- 14. Synthesis and characterization of novel bioactive azo compounds fused with benzothiazole and their versatile biologi
- 15. Strong binding of Leupeptin with TMPRSS2 protease may be an alternative to Camostat and Nafamostat for SARS-CoV-2 re
- 16. Binding mechanism of naringenin with monoamine oxidase – B enzyme: QM/MM and molecular dynamics perspective
- 17. Investigation of intermolecular interactions and binding mechanism of PU139 and PU141 molecules with p300 HAT enzyme
- 18. Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors.
- 19. Influence of green tea on alcohol aggravated neurodegeneration of cortex, cerebellum and hippocampus of STZ-induced
- 20. Gelatin/polyethylene glycol-loaded magnesium hydroxide nanocomposite to attenuate acetylcholinesterase, neurotoxicit
- 21. Spectroscopic, DFT investigation and active site analysis of 2,2-diphenyl-1,3-propanediol against estrogen receptor
- 22. Synthesis, crystal structure, spectroscopic and computational studies of NLO active 2-methylimdazolium 4-nitrobenzoi
- 23. Unrevealing Biosynthesis of Zinc Oxide Nanoparticles Using Laggera alata Leaf Extract: Evaluation of Antioxidant, An
- 24. Exploring Antibacterial, Antioxidant, Cytotoxic Potential of Oscillatoria sp.‑Derived Metabolites and Their Molecula
- 25. A Dual-Target Inhibitor of α-Terpineol in Alzheimer's and Parkinson's Diseases: A Comprehensive Active Site Analysis
- 26. Phosphorus doped 2D polymeric graphitic carbon nitride biomaterial: Biological activity and DFT insights with nitrof
- I worked as a Research Assistant in the Bioinformatics Centre, Department of Physics, Manonmanium Sundaranar University, Tirunelveli - 627 012, Tamilnadu, India funded by the Department of Biotechnology, New Delhi, Government of India, During April 1st 2013 to November 30th 2013
- Guest Lecturer, Department of Physics, Periyar University, Salem, Tamilnadu, India (From 8.8.2019 to 25.3.2021).
- I worked as a Post-Doctoral Fellow in Laboratory of Biological Physics, Institute of Physics, Polish Academy of Sciences, Warsaw, Poland from 3.4.2021 to 2.4.2022.
- Established the remote login access to use HPC (High Performance Computing) facility available in Centre for Development of Advanced Computing (C-DAC) [Under -Ministry of Electronics and Information Technology (MeitY) and Ministry of Communications and Information Technology] Government of India, Bioinformatics Research and Applications Facility (BRAF), Innovation Park C-DAC, Pune.
- Received Travel grant to attend the Bioexcel and PRACE joint course on "Hands-on Introduction to HPC for Life Scientists" organized by European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridgeshire, UK
